Research Projects

Spatial Transcriptomics Alignment

Advisor: Hongyu Zhao, Yale University, School of Public Health

Period: March 2025 - Present

Status: Manuscript in preparation

Keywords: Spatial Transcriptomics · Optimal Transport · Graph Attention Network

Innovation

• Designed an iterative approach for spatial transcriptomics alignment and deconvolution
• Use cell-type proportion as a biologically interpretable embedding for optimal transport

Cross-Study Debiasing for Microbiome Data

Advisor: Guanhua Chen, University of Wisconsin-Madison, School of Medicine and Public Health

Period: October 2025 - Present

Status: Manuscript in preparation

Keywords: Microbiome · Batch-effect Correction · Aitchison geometry

Innovation

• Constructed a cross-study debias framework for microbiome analysis
• Operates directly on the simplex space
• Adjusts for confounding covariates

Multimodal Deep Learning Model for Laryngeal Cancer Diagnosis

Advisor:Kewei Liang, Zhejiang University, School of Mathematical Sciences

Period: March 2024 - November 2026

Status: Preprint on SSRN, Under review at International Journal of Surgery

Keywords: Multimodal Fusion · Deep Learning · Risk Score

Innovation

• Constructed a multimodal deep-learning framework for laryngeal cancer risk prediction
• Performance evaluated across three external cohorts